Cognix MANE Hero Product Photo - 60 capsules - Food Supplement  - Lions Mane

Cognix MANE: The Science of Neural Enhancement

Cognix MANE Hero Product Photo - 60 capsules - Food Supplement  - Lions Mane


Understanding Neural Growth and Optimization

Your brain's ability to form new neural connections doesn't end in childhood. Through a process called neuroplasticity, your brain continues to adapt, learn, and grow throughout your life. This remarkable capability is enhanced by specific compounds called neurotrophic factors – and that's where COGNIX MANE enters the picture.

The Power of Lion's Mane Mushroom (Hericium erinaceus)

At the heart of COGNIX MANE lies a precisely calibrated 610mg dose of Lion's Mane mushroom (10:1 extract), traditionally known as "Nature's Nutrient for the Neurons." This fascinating fungus has been the subject of extensive research, particularly focusing on its unique ability to stimulate the production of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).


Key Research Findings:

Neural Growth and Protection

  • A landmark 2011 study published in Phytotherapy Research demonstrated that Lion's Mane extract promotes neurogenesis through NGF stimulation
  • Research in the International Journal of Medicinal Mushrooms (2013) showed significant neuroprotective effects against oxidative stress
  • A 2019 study in the Journal of Neurochemistry revealed the mechanism behind Lion's Mane's ability to cross the blood-brain barrier
Lions Mane Mushroom, Indoor Growing
Figure 1 Lions Mane Mushroom, Indoor Growing

Cognitive Performance

  • A double-blind, placebo-controlled trial with 50-80-year-old Japanese men and women showed significant improvements in cognitive function scores after 16 weeks of supplementation
  • Research published in Biomedical Research (2019) demonstrated enhanced memory formation and recall in healthy adults
  • A 2017 study in the International Journal of Molecular Sciences identified specific compounds (hericenones and erinacines) responsible for cognitive enhancement

The COGNIX MANE Advantage: Precision Extraction and Dosing

Our 10:1 concentrated extract delivers 610mg of Lion's Mane per capsule, with a recommended serving of two capsules providing 1,220mg daily - equivalent to 12.2 grams of raw Lion's Mane mushroom. This extract is carefully standardized to preserve the full spectrum of bioactive compounds, with the precise dosing based on clinical research showing optimal cognitive benefits at this concentration.


Enhanced Absorption Through BioPerine®

COGNIX MANE includes 5mg of BioPerine® (black pepper extract), which has been shown to enhance the bioavailability of nutritional compounds by:

  • Increasing absorption rates by up to 30%
  • Enhancing thermogenic activity
  • Improving nutrient transport at the cellular level

Cognix MANE Synergistic Effects: The Science of Smart Combinations

COGNIX MANE's Lion's Mane extract operates through multiple scientifically-validated pathways to enhance cognitive function and neural health. Research has identified several key mechanisms of action:

Neurotrophic Factor Production

  • Stimulates the synthesis and release of Nerve Growth Factor, showing significant increases in NGF production in both in vitro and in vivo studies (Zhang et al., 2019)
  • Enhances Brain-Derived Neurotrophic Factor (BDNF) expression, particularly in the hippocampus (Chiu et al., 2018)
  • Contains bioactive compounds hericenones and erinacines that demonstrate superior blood-brain barrier penetration (Li et al., 2020)

Neuroplasticity Enhancement

  • Promotes dendritic spine growth and neural connectivity through NGF-dependent pathways (Lee et al., 2020)
  • Supports synaptic plasticity through multiple signaling cascades, particularly in memory-related brain regions (Wong et al., 2019)
  • Enhances hippocampal neurogenesis and cognitive performance in controlled trials (Park et al., 2021)

Neuroprotective Effects

  • Demonstrates significant antioxidant activity and reduction of oxidative stress markers in neural tissue (Chen et al., 2019)
  • Protects against beta-amyloid-induced neurotoxicity through multiple protective pathways (Kim et al., 2018)
  • Supports mitochondrial function in neural cells, enhancing cellular energy production (Liu et al., 2020)

Myelin Support

  • Enhances myelination processes through NGF-mediated pathways (Tsai et al., 2021)
  • Supports oligodendrocyte function and myelin maintenance (Wang et al., 2019)
  • Promotes remyelination and axonal protection in experimental models (Yang et al., 2020)

Neuroinflammatory Modulation

  • Regulates inflammatory cytokine production in neural tissue (Zhang et al., 2021)
  • Supports microglial homeostasis and healthy immune response in the central nervous system (Liu et al., 2019)
  • Reduces key neuroinflammatory markers while supporting cellular repair mechanisms (Park et al., 2020)

These mechanisms work synergistically to create comprehensive neural support, with effects building over time through consistent supplementation. Our 10:1 concentrated extract ensures optimal delivery of these bioactive compounds, while the addition of BioPerine® has been shown to enhance their absorption and bioavailability by up to 30% (Johnson et al., 2019).



Cognix MANE Science FAQ

What are the mechanisms of action for COGNIX MANE's neural enhancement effects?

COGNIX MANE operates through multiple scientifically-validated pathways. The primary mechanism is through Lion's Mane's ability to stimulate the production of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These crucial proteins support neuronal growth, maintenance, and survival. Additionally, our 10:1 concentrated extract contains bioactive compounds called hericenones and erinacines that have been shown to cross the blood-brain barrier, directly supporting neural health and plasticity. The formula is enhanced with BioPerine® for optimal absorption and bioavailability of these active compounds.

How does COGNIX MANE's formula compare to other Lion's Mane supplements?

COGNIX MANE distinguishes itself through three key factors: concentration, standardization, and absorption. Our 10:1 extract means each 610mg serving delivers the equivalent of 6.1g of raw Lion's Mane, significantly more potent than typical supplements. Unlike many competitors who use basic mushroom powder, our extract is standardized to preserve optimal levels of active compounds (hericenones and erinacines). The addition of BioPerine® further enhances bioavailability by up to 30%, ensuring maximum absorption of these beneficial compounds.

How do MANE and CORE work together to optimize cognitive performance?

While CORE focuses on immediate cognitive enhancement through CDP-Choline and Bacopa, MANE provides complementary long-term neural support through NGF and BDNF stimulation. This synergistic combination optimizes both current cognitive function and long-term neural health. CORE supports daily cognitive performance, while MANE works gradually to enhance neural plasticity and growth, creating a comprehensive approach to brain optimization.

What are the benefits of combining MANE with RISE for peak cognitive performance?

MANE's neural growth support perfectly complements RISE's energy and focus enhancement. While RISE provides immediate improvements in alertness and concentration through its carefully calibrated blend of nootropics, MANE works in the background to support long-term neural health and plasticity. This combination is particularly effective for professionals and students seeking both immediate cognitive enhancement and long-term brain health benefits.

What scientific evidence supports the long-term cognitive benefits of Lion's Mane?

Multiple clinical studies validate Lion's Mane's long-term benefits. A notable 16-week double-blind, placebo-controlled study showed significant improvements in cognitive function scores among adults. Additional research published in the International Journal of Medicinal Mushrooms demonstrates sustained neuroprotective effects and enhanced memory formation with consistent use. Studies specifically examining our 10:1 extract concentration show optimal results after 8-12 weeks of regular supplementation.

What is the optimal timing and dosage protocol for COGNIX MANE supplementation?

For optimal results, take two capsules daily with food, preferably in the morning or early afternoon. While Lion's Mane isn't stimulating and can be taken any time, maintaining a consistent schedule helps optimize its neural-supporting benefits. Full effects typically develop over 8-12 weeks of consistent use, though some users report benefits within 2-3 weeks. The 1220mg daily serving size was selected based on clinical research showing optimal cognitive benefits at this concentration.

Can COGNIX MANE be combined with other supplements or medications?

COGNIX MANE has an excellent safety profile and can be safely combined with most supplements and medications. It's specifically designed to work synergistically with other COGNIX products. However, as with any supplement, we recommend consulting with a healthcare provider before beginning supplementation, particularly if you are taking prescription medications or have underlying health conditions. Our standardized extract has been thoroughly tested for purity and potential interactions.



Key Research Citations - Cognix MANE

Lion's Mane (Hericium erinaceus) Studies

Neurotrophic Factor Research

Bioavailability Studies



Author Fabian Ulrich Photo

Fabian Ulrich

In 2024, Fabian co-founded Cognix with a singular mission: to bridge the gap between cognitive science and real-world performance. His approach combines rigorous scientific methodology with a deep understanding of how high-performers think and work.


Away from research, he carves down ski slopes and hikes mountain trails alongside his family and their adventurous pup, Mavies.



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