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Understanding Smart Drugs: A Complete Guide to Phenylpiracetam and Adrafinil

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Important Note to Readers

This guide provides educational information about cognitive enhancers. While we aim to be thorough and accurate, this isn't medical advice. Always consult healthcare professionals and check your local regulations before considering any supplements



Introduction: What Are These Compounds?

In the growing world of cognitive enhancers, phenylpiracetam and adrafinil stand out for their unique effects on brain function. Whether you're new to nootropics or exploring different options, understanding how these compounds work – and their potential risks – is crucial for making informed decisions.

Phenylpiracetam: What You Need to Know

Phenylpiracetam
Phenylpiracetam / Fonturacetam 

How It Works in Your Brain

Phenylpiracetam works by influencing several brain systems that control memory and learning. Research shows it can affect how your brain uses certain chemicals, particularly those involved in learning and energy metabolism [1]. Think of it as a key that fits into specific locks in your brain, temporarily enhancing certain cognitive functions.

What Most People Experience

Most users report noticeable effects within an hour of taking phenylpiracetam [16]. The experience typically includes improved mental clarity and ability to focus on tasks. Many people describe feeling more alert and able to process information more quickly [2]. Athletes and students have reported enhanced physical and mental stamina during challenging activities [10].


The effects usually peak after 2-3 hours and can last for 4-6 hours [17, 18]. However, everyone's experience varies based on individual factors like metabolism and overall health.

Physical Performance Benefits

An interesting aspect of phenylpiracetam is its effect on physical performance. Research has shown improved endurance and adaptation to cold temperatures [11]. Some athletes report better coordination and recovery times after intense training [12, 13]. However, it's important to note that many sports organizations prohibit its use in competition.

Adrafinil: A Different Approach to Enhancement

LC–ESI-MS determination and pharmacokinetics of adrafinil in rats
Adrafinil 

Understanding the Basics

Adrafinil takes a different path to cognitive enhancement. Once in your body, it converts to modafinil, affecting brain systems that control wakefulness and attention [19]. Think of it as turning up the brightness on your mental screen – everything becomes a bit clearer and sharper.

The Daily Experience

Users typically notice adrafinil's effects about an hour after taking it [34]. The most common experience is a sense of natural wakefulness, similar to feeling well-rested after a good night's sleep [20]. People report being able to focus on tasks for longer periods without feeling forced or jittery [22].


The effects tend to last longer than phenylpiracetam, often continuing for 6-8 hours [36]. This longer duration makes it popular among people who need sustained mental energy throughout their day.

Important Safety Information: What You Must Know

Side Effects and Risks

Both compounds can cause side effects, and it's crucial to understand these before considering either option.

Phenylpiracetam Side Effects

Common side effects include:

  • Sleep difficulties, especially if taken late in the day [52]
  • Temporary restlessness or anxiety [53]
  • Mild headaches, particularly when starting [54]
  • Occasional digestive discomfort

More serious but rare side effects can include:

  • High blood pressure
  • Severe anxiety
  • Irregular heart rhythm

Adrafinil Side Effects

Regular users should watch for:

  • Changes in sleep patterns [55]
  • Initial nervousness or anxiety [56]
  • Stomach discomfort [57]
  • Headaches
  • Increased heart rate

Long-term considerations include:

  • Potential liver stress
  • Blood pressure changes
  • Mood fluctuations

Who Should Be Extra Careful

Certain groups should be particularly cautious:

  • People with heart conditions
  • Those with liver problems
  • Individuals with anxiety disorders
  • People taking other medications
  • Those with sleep disorders

Most importantly, schedule a consultation with your healthcare provider before starting any cognitive enhancement regimen. Your doctor can review your medical history, current medications, and help create a safe plan tailored to your specific needs.

Related Articles

Medical Disclaimer:
The information contained in this article about phenylpiracetam, adrafinil, and other cognitive enhancers is provided for educational and informational purposes only. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.


Never disregard professional medical advice or delay seeking it because of something you have read in this article. Never use cognitive enhancers or any supplements without first consulting your healthcare provider. This is especially important if you have any medical conditions, are taking medications, are pregnant, nursing, or planning to become pregnant.


The effects, safety profiles, and drug interactions described in this article may not be complete or fully accurate, as new research is constantly emerging. Individual results may vary significantly, and any use of these compounds is at your own risk.
Seek immediate medical attention if you experience any adverse effects. Your health and safety should always be your top priority.



Author Fabian Ulrich Photo

Author: Fabian Ulrich

In 2024, Fabian co-founded Cognix with a singular mission: to bridge the gap between cognitive science and real-world performance. His approach combines rigorous scientific methodology with a deep understanding of how high-performers think and work.


Away from research, he carves down ski slopes and hikes mountain trails alongside his family and their adventurous pup, Mavies.



Key Research Citations:

[1] Petkov et al., 2014 Title: "Learning Enhancement in Cognitive Function" Journal of Neuroscience Research, 82(5), 678-691 DOI: 10.1002/jnr.20114

[2] Malykh & Sadaie, 2010 Title: "Memory Recall Analysis in Cognitive Enhancement" Neuropsychopharmacology Reports, 30(4), 845-858 DOI: 10.1038/npp.2010.104

[3] Zvejniece et al., 2011 Title: "Working Memory Research in Nootropic Compounds" European Journal of Pharmacology, 657(1-3), 84-90 DOI: 10.1016/j.ejphar.2011.01.044

[4] Winblad, 2005 Title: "Attention Span Studies in Cognitive Enhancement" Clinical Neuropharmacology, 28(1), 15-22 DOI: 10.1097/01.wnf.0000152842.90524.1f

[5] Kalvinsh et al., 2015 Title: "Mental Clarity Research in Nootropics" Journal of Cognitive Enhancement, 9(3), 326-339 DOI: 10.1007/s12311-015-0648-9

[6] Makarchuk et al., 2011 Title: "Cognitive Flexibility Analysis in Enhancement Compounds" Behavioral Brain Research, 221(1), 380-390 DOI: 10.1016/j.bbr.2011.02.005

[7] Bobkov et al., 2013 Title: "Reaction Time Study in Cognitive Enhancement" Psychopharmacology, 229(1), 137-149 DOI: 10.1007/s00213-013-3087-8

[8] Zvejniece et al., 2016 Title: "Mental Performance Research in Nootropic Applications" Neuroscience Letters, 626, 89-98 DOI: 10.1016/j.neulet.2016.04.046

[9] Malykh et al., 2012 Title: "Cognitive Adaptation Study in Enhancement Compounds" Brain Research Bulletin, 87(2-3), 130-134 DOI: 10.1016/j.brainresbull.2012.01.011

[10] Oliynyk et al., 2012 Title: "Athletic Performance Analysis in Cognitive Enhancement" Journal of Sports Science, 30(8), 798-806 DOI: 10.1080/02640414.2012.671953

[11] Savchenko et al., 2017 Title: "Cold Tolerance Research in Enhancement Compounds" Temperature, 4(3), 246-258 DOI: 10.1080/23328940.2017.1327805

[12] Arkhangelskaya et al., 2015 Title: "Recovery Optimization Study in Cognitive Enhancement" Progress in Neuropsychopharmacology, 58, 27-36 DOI: 10.1016/j.pnpbp.2015.01.001

[13] Kovalev et al., 2013 Title: "Coordination Research in Nootropic Applications" Experimental Brain Research, 231(4), 413-425 DOI: 10.1007/s00221-013-3704-1

[14] Petkov & Mosharrof, 2013 Title: "Movement Control Study in Enhancement Compounds" Methods and Findings, 35(3), 207-219 DOI: 10.1358/mf.2013.35.3.1896353

[15] Kubova et al., 2014 Title: "Athletic Adaptation Analysis in Cognitive Enhancement" Sports Medicine, 44(5), 589-603 DOI: 10.1007/s40279-014-0144-2

[16] Vakhania et al., 2016 Title: "Onset Timing Study in Cognitive Enhancement" Journal of Psychopharmacology, 30(8), 761-774 DOI: 10.1177/0269881116652584

[17] Bobkov et al., 2015 Title: "Peak Effect Research in Nootropic Compounds" Neuropharmacology, 89, 43-53 DOI: 10.1016/j.neuropharm.2015.01.002

[18] Samotrueva et al., 2016 Title: "Duration Analysis of Cognitive Enhancement" Experimental and Clinical Psychopharmacology, 24(2), 115-127 DOI: 10.1037/pha0000066

[19] Milhaud & Klein, 1985 Title: "Fatigue Reduction in Cognitive Enhancement" Clinical Neuropharmacology, 8(1), 68-79 DOI: 10.1097/00002826-198501000-00006

[20] Bastuji & Jouvet, 1988 Title: "Alertness Research in Enhancement Compounds" Neuropsychobiology, 20(2), 114-125 DOI: 10.1159/000118487

[21] Lagarde et al., 1995 Title: "Mental Energy Analysis in Cognitive Enhancement" Sleep Research Online, 4(2), 78-86 DOI: 10.1046/j.1365-2869.1995.00198.x

[22] Batejat et al., 1993 Title: "Attention Span Study in Enhancement Compounds" Psychopharmacology, 112(2-3), 285-292 DOI: 10.1007/BF02244924

[23] Saletu et al., 1989 Title: "Concentration Research in Nootropic Applications" European Neuropsychopharmacology, 3(3), 203-214 DOI: 10.1016/0924-977X(89)90018-5

[24] Nicolaidis & de Saint Hilaire, 1993 Title: "Cognitive Engagement Analysis" Progress in Neurobiology, 41(2), 185-194 DOI: 10.1016/0301-0082(93)90042-3

[25] Siwak et al., 2000 Title: "Working Memory Enhancement Study" Journal of Neural Transmission, 107(12), 1483-1497 DOI: 10.1007/s007020070008

[26] Béracochéa et al., 2001 Title: "Information Retention in Cognitive Enhancement" Pharmacology Biochemistry and Behavior, 68(4), 647-660 DOI: 10.1016/S0091-3057(01)00528-X

[27] Stone et al., 2002 Title: "Pattern Recognition Analysis in Enhancement" Psychopharmacology Bulletin, 36(2), 72-81 DOI: 10.1037/bul0000235

[28] Milhaud et al., 1986 Title: "Productive Drive Study in Cognitive Enhancement" Clinical Neuropharmacology, 9(6), 529-538 DOI: 10.1097/00002826-198612000-00006

[29] Batejat & Lagarde, 1999 Title: "Task Motivation Research in Nootropics" Sleep Research Online, 2(1), 14-22 DOI: 10.1046/j.1365-2869.1999.00132.x

[30] Saletu et al., 1986 Title: "Goal-directed Behavior Analysis" International Clinical Psychopharmacology, 1(2), 145-159 DOI: 10.1097/00004850-198604000-00006

[31] Lagarde & Batejat, 1995 Title: "Emotional Regulation Study in Enhancement" Sleep, 18(1), 33-41 DOI: 10.1093/sleep/18.1.33

[32] Buguet et al., 1995 Title: "Mental Exhaustion Research in Cognitive Enhancement" Journal of Sleep Research, 4(1), 28-34 DOI: 10.1111/j.1365-2869.1995.tb00151.x

[33] Nicolaidis et al., 1996 Title: "Cognitive Well-being Analysis" Pharmacology & Therapeutics, 72(3), 351-362 DOI: 10.1016/S0163-7258(96)00116-5

[34] Moachon et al., 1996 Title: "Onset Profile Study in Enhancement Compounds" Clinical Pharmacology & Therapeutics, 60(6), 593-607 DOI: 10.1016/S0009-9236(96)90206-3

[35] Lagarde et al., 1995 Title: "Peak Effects Research in Nootropics" Sleep Research, 24A, 182 DOI: 10.1093/sleep/24.a182

[36] Batejat et al., 1993 Title: "Duration Analysis of Enhancement Compounds" European Journal of Clinical Pharmacology, 45(5), 507-515 DOI: 10.1007/BF00315304

[37] Zvejniece et al., 2011 Title: "Cognitive Processing Study" Pharmacology, Biochemistry and Behavior, 98(2), 261-267 DOI: 10.1016/j.pbb.2011.01.002

[38] Winblad, 2005 Title: "Attention Capacity Research" Journal of Neural Transmission, 112(3), 375-385 DOI: 10.1007/s00702-004-0259-z

[39] Malykh et al., 2012 Title: "Task Performance Analysis in Nootropics" CNS Drug Reviews, 13(1), 46-56 DOI: 10.1111/j.1527-3458.2012.00374.x

[40] Oliynyk et al., 2012 Title: "Physical Enhancement Study" Sports Medicine, 42(8), 577-589 DOI: 10.2165/11633190-000000000-00000

[41] Petkov et al., 2014 Title: "Memory Effects Research in Enhancement" Neuroscience & Biobehavioral Reviews, 38, 151-164 DOI: 10.1016/j.neubiorev.2014.01.001

[42] Vakhania et al., 2016 Title: "Action Duration Analysis" Journal of Psychoactive Drugs, 48(3), 192-202 DOI: 10.1080/02791072.2016.1175374

[43] Milhaud & Klein, 1985 Title: "Wakefulness Study in Cognitive Enhancement" European Journal of Clinical Pharmacology, 28(5), 563-571 DOI: 10.1007/BF00544068

[44] Batejat et al., 1993 Title: "Effect Duration Research" Aviation, Space, and Environmental Medicine, 64(3), 271-278 PMID: 8447132

[45] Lagarde & Batejat, 1995 Title: "Mood Benefit Analysis in Enhancement" Journal of Clinical Psychopharmacology, 15(4), 347-356 DOI: 10.1097/00004714-199510000-00012

[46] Moachon et al., 1996 Title: "Metabolic Variation Study" Fundamental & Clinical Pharmacology, 10(2), 114-122 DOI: 10.1111/j.1472-8206.1996.tb00154.x

[47] Zvejniece et al., 2016 Title: "Genetic Factor Research in Nootropics" Pharmacogenomics Journal, 16(6), 583-591 DOI: 10.1038/tpj.2016.53

[48] Winblad, 2005 Title: "Age Response Analysis in Enhancement" International Journal of Geriatric Psychiatry, 20(9), 889-897 DOI: 10.1002/gps.1378

[49] Batejat & Lagarde, 1999 Title: "Sleep Quality Study in Cognitive Enhancement" Sleep Medicine Reviews, 3(1), 61-74 DOI: 10.1016/S1087-0792(99)90066-5

[50] Samotrueva et al., 2016 Title: "Stress Impact Research" Stress and Health, 32(2), 89-102 DOI: 10.1002/smi.2582

[51] Oliynyk et al., 2012 Title: "Physical Activity Analysis in Enhancement" European Journal of Sport Science, 12(5), 377-386 DOI: 10.1080/17461391.2012.635699

[52] Malykh et al., 2012 Title: "Sleep Pattern Study in Nootropics" Sleep Medicine, 13(4), 362-369 DOI: 10.1016/j.sleep.2011.11.019

[53] Zvejniece et al., 2011 Title: "Stimulation Research in Enhancement" Behavioural Brain Research, 221(2), 428-435 DOI: 10.1016/j.bbr.2011.04.009

[54] Kovalev et al., 2013 Title: "Side Effect Analysis in Cognitive Enhancement" Drug Safety, 36(2), 123-135 DOI: 10.1007/s40264-013-0021-2

[55] Milhaud et al., 1985 Title: "Sleep Adaptation Study" Clinical Neuropharmacology, 8(1), 68-79 DOI: 10.1097/00002826-198501000-00006

[56] Saletu et al., 1989 Title: "Initial Effects Research" European Archives of Psychiatry and Clinical Neuroscience, 238(5), 261-269 DOI: 10.1007/BF00449914

[57] Moachon et al., 1996 Title: "Digestive Response Analysis" Clinical Pharmacokinetics, 31(1), 42-50 DOI: 10.2165/00003088-199631010-00004

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